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Chronic Fatigue Syndrome

Chronic Fatigue Syndrome, also known as Myalgic Encephalomyelitis, is a complex condition characterized by profound fatigue that is not relieved by rest and is often worsened by physical or mental activity. The…

4 MIN READ· PHYSICIAN-REVIEWED· UPDATED 2026

Chronic Fatigue Syndrome, also known as Myalgic Encephalomyelitis, is a complex condition characterized by profound fatigue that is not relieved by rest and is often worsened by physical or mental activity. The condition can significantly affect daily functioning and quality of life.

Because symptoms can overlap with autoimmune, inflammatory, or neurologic conditions, comprehensive evaluation is important.

What Is Chronic Fatigue Syndrome?

Chronic Fatigue Syndrome is a multisystem condition involving persistent fatigue and impaired energy regulation. It is not caused by ongoing exertion and does not improve substantially with rest.

The condition may involve abnormalities in immune, neurologic, or metabolic function, though the exact mechanisms are not fully understood.

Common Symptoms

Symptoms of chronic fatigue syndrome may include:

  • Severe, persistent fatigue
  • Post-exertional symptom worsening
  • Unrefreshing sleep
  • Muscle or joint pain
  • Headaches
  • Difficulty concentrating or memory issues
  • Lightheadedness or dizziness

Symptoms may vary in intensity and duration.

What Causes Chronic Fatigue Syndrome?

The precise cause is not known, but contributing factors may include:

  • Immune system dysregulation
  • Infections triggering prolonged symptoms
  • Neurologic or metabolic abnormalities
  • Genetic susceptibility

Multiple mechanisms may be involved.

How Is Chronic Fatigue Syndrome Diagnosed?

Diagnosis is clinical and often involves excluding other conditions. Evaluation may include:

  • Detailed symptom history
  • Physical examination
  • Laboratory testing to rule out inflammatory or autoimmune diseases
  • Assessment of symptom duration and functional impact

Diagnosis typically requires symptoms to be present for an extended period.

Treatment Options for Chronic Fatigue Syndrome

Management focuses on symptom control and functional support. Options may include:

  • Activity pacing strategies
  • Sleep and energy management approaches
  • Supportive therapies to address pain or cognitive symptoms
  • Multidisciplinary care when appropriate
  • Infusion-based treatments are not typically indicated

Treatment plans are tailored to individual needs.

When to See a Rheumatologist

A rheumatology evaluation may be appropriate if you experience:

  • Persistent fatigue with musculoskeletal symptoms
  • Overlapping joint or muscle pain
  • Abnormal autoimmune blood tests
  • Unclear cause of ongoing symptoms

Specialized assessment can help guide diagnosis.

Our Approach to Treating Chronic Fatigue Syndrome

Our approach emphasizes comprehensive evaluation, symptom management, and coordinated care. We work to identify contributing factors and support patients in managing symptoms and daily function.

Schedule a Consultation

If persistent fatigue is limiting your quality of life, scheduling a consultation can help clarify the diagnosis and explore supportive management options.

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